Роль андрогенов в развитии ожирения и сахарного диабета 2-го типа

Демидова Т.Ю., Скуридина Д.В. Роль андрогенов в развитии ожирения и сахарного диабета 2-го типа. FOCUS Эндокринология. 2021; 1: 25–30. DOI: 10.47407/ef2021.2.1.0020

Demidova T.Y., Skuridina D.V. The role of androgens in the development of obesity and type 2 diabetes. FOCUS Endocrinology. 2021; 1: 25–30. DOI: 10.47407/ef2021.2.1.0020

Цель. Обобщить современные данные о роли уровней андрогенов в развитии ожирения, сахарного диабета 2-го типа (СД 2) и кардиометаболического синдрома и выделить актуальные направления разработки эффективных терапевтических методов.

Материалы и методы. Обзор фундаментальных, клинических и экспериментальных данных проводился в базах данных научной литературы (PubMed) преимущественно с 2015 по 2020 г., посвященных роли гипогонадизма в развитии ожирения и СД 2 и терапевтическим возможностям назначения тестостеронзаместительной терапии.

Результаты. Существуют важные механизмы, влияющие на уровни андрогенов и риск развития кардиометаболического синдрома, в частности ожирения и СД 2. Андрогенный дефицит является самостоятельным фактором риска развития висцерального ожирения, инсулинорезистентности, ожирения и СД 2, повышает риск сердечно-сосудистых заболеваний и смерти.

Заключение. Тестостерон может играть профилактическую роль в развитии абдоминального ожирения, метаболического синдрома и последующего СД 2. Весомая роль андрогенов в развитии кардиометаболических заболеваний диктует необходимость проведения крупных проспективных популяционных исследований тестостеронзаместительной терапии у пациентов с ожирением и СД 2.

Ключевые слова: андрогены, тестостерон, ожирение, сахарный диабет 2-го типа, гипогонадизм, андрогенный дефицит.

Демидова Татьяна Юльевна - д-р мед. наук, проф., зав. каф. эндокринологии лечебного факультета ФГАОУ ВО «РНИМУ им. Н.И. Пирогова». E-mail: t.y.demidova@gmail.com; ORCID: 0000-0001-6385-540X; eLIBRARY.RU SPIN: 9600-9796; Scopus Author ID: 7003771623
Скуридина Дарья Викторовна - ассистент каф. эндокринологии лечебного факультета ФГАОУ ВО «РНИМУ им. Н.И. Пирогова». E-mail: shurpesha@mail.ru; ORCID: 0000-0002-6899-4457

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