Метформин является препаратом 1-й линии для лечения диабета 2 типа, при этом он имеет долгую историю применения в лечении инфекционных заболеваний, таких как грипп, гепатит С и вирус Зика. В условиях нынешней пандемии COVID-19, которая быстро распространилась по всему миру, были опубликованы 4 обсервационных исследования, показавших снижение смертности среди лиц, применяющих метформин в амбулаторных условиях. Существует несколько потенциальных механизмов, с помощью которых метформин может снизить смертность от COVID-19. Возможные такого рода эффекты метформина были связаны как непосредственно с инфекционным агентом (вирусом), так и с улучшением метаболического статуса пациента. Неизвестно, обусловлена ли более низкая смертность, предполагаемая обсервационными исследованиями, у пациентов, инфицированных COVID-19, которые принимают метформин, прямой активностью против самого вируса, улучшением состояния пациента или и тем и другим.
Ключевые слова: сахарный диабет, метформин, COVID-19
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