Дисфункция филометаболического ядра микробиоты в патогенезе сахарного диабета 2-го типа
Демидова Т.Ю., Ардатская М.Д. Дисфункция филометаболического ядра микробиоты в патогенезе сахарного диабета 2-го типа. FOCUS Эндокринология. 2021; 3: 16–23. DOI: 10.47407/ef2021.2.3.0030
Demidova T.Yu., Ardatskaya M.D. The phylometabolic core of intestinal microbiota dysfunction in the pathogenesis of diabetes mellitus. FOCUS Endocrinology. 2021; 3: 16–23. DOI: 10.47407/ef2021.2.3.0030
Филометаболическое ядро – набор эволюционно стабильных видов микроорганизмов, отвечающих за большинство основных метаболических функций кишечной микробиоты. Дисфункция филометаболического ядра, проявляющаяся нарушением соотношения его основных компонентов и качественным и количественным изменением концентраций их ключевых метаболитов, является фактором возникновения и прогрессирования многих заболеваний, в том числе сахарного диабета 2-го типа (СД 2). В обзорной статье представлены актуальные клинические данные, свидетельствующие о перспективности применения пищевых волокон для коррекции нарушений микробиоты и улучшения течения СД 2. Частично гидролизованные пищевые волокна циамопсиса в составе препарата ОптиФайбер оказывают модулирующее воздействие на баланс ключевой микробиоты и способствуют восстановлению ее нормальной метаболической функции, обеспечивая тем самым коррекцию обменных процессов, повышение чувствительности тканей к инсулину, снижение постпрандиальной гликемии и облегчение течения заболевания в целом.
Ключевые слова: микробиота, филометаболическое ядро, метаболический дисбиоз, короткоцепочечные жирные кислоты, пищевые во-локна, циамопсис, сахарный диабет 2-го типа.
Ключевые слова: микробиота, филометаболическое ядро, метаболический дисбиоз, короткоцепочечные жирные кислоты, пищевые во-локна, циамопсис, сахарный диабет 2-го типа.
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2. Qin J, Li R, Raes J et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464 (7285): 59–65.
3. Reichardt N, Duncan SH, Young P, Belenguer A et al. Phylogenetic distribu-tion of three pathways for propionate production within the human gut mi-crobiota. ISME J 2014; 8 (6): 1323–35.
4. Ситкин С.И., Ткаченко Е.И., Вахитов Т.Я. Филометаболическое ядро микробиоты кишечника. Альманах клинической медицины. 2015; 40: 12–34.
[Sitkin S.I., Tkachenko E.I., Vakhitov T.Ya. Phylometabolic core of intestinal microbiota. Almanac of Clinical Medicine. 2015; 40:12–34 (in Russian)].
5. Zhang J, Guo Z, Xue Z et al. A phylo-functional core of gut microbiota in healthy young Chinese cohorts across lifestyles, geography and ethnicities. ISME J 2015; 9 (9): 1979–90.
6. Dai ZL, Wu G, Zhu WY. Amino acid metabolism in intestinal bacteria: links between gut ecology and host health. Front Biosci (Landmark Ed) 2011; 16: 1768–86.
7. Yu LC, Wang JT, Wei SC, Ni YH. Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology. World J Gastrointest Pathophysiol 2012; 3 (1): 27–43.
8. Shafquat A, Joice R, Simmons SL, Huttenhower C. Functional and phyloge-netic assembly of microbial communities in the human microbiome. Trends Microbiol 2014; 22 (5): 261–6.
9. Neis EP, Dejong CH, Rensen SS. The role of microbial amino acid metabolism in host metabolism. Nutrients 2015; 7 (4): 2930–46.
10. Marín L, Miguélez EM, Villar CJ, Lombó F. Bioavailability of dietary polyphe-nols and gut microbiota metabolism: antimicrobial properties. Biomed Res Int 2015; 2015: 905215.
11. Arumugam M, Raes J, Pelletier E et al. Enterotypes of the human gut micro-biome. Nature 2011; 473 (7346): 174–80.
12. Tap J et al. Towards the human intestinal microbiota phylogenetic core. En-viron Microbiol 2009; 11 (10): 2574–84.
13. Rey FE et al. Dissecting the in vivo metabolic potential of two human gut acetogens. J Biol Chem 2010; 285 (29): 22082–90.
14. Vital M, Howe AC, Tiedje JM. Revealing the bacterial butyrate synthesis pathways by analyzing (meta)genomic data. MBio 2014; 5 (2): e00889.
15. Louis P, Flint HJ. Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine. FEMS Microbiol Lett 2009; 294 (1): 1–8.
16. Pozuelo M, Panda S, Santiago A et al. Reduction of butyrate- and methane-pro-ducing microorganisms in patients with Irritable Bowel Syndrome. Sci Rep 2015; 5: 12693.
17. Nylund L, Nermes M, Isolauri E et al. Severity of atopic disease inversely corre-lates with intestinal microbiota diversity and butyrate-producing bacteria. Al-lergy 2015; 70 (2): 241–4.
18. Le Chatelier E, Nielsen T, Qin J et al. Richness of human gut microbiome corre-lates with metabolic markers. Nature 2013; 500 (7464): 541–6.
19. Ситкин С.И., Ткаченко Е.И., Вахитов Т.Я. Метаболический дисбиоз ки-шечника и его биомаркеры. Экспериментальная и клиническая га-строэнтерология. 2015; 124 (12): 6–29.
[Sitkin S.I., Vakhitov T.Y. Metabolic dysbiosis of the gut microbiota and its biomarkers. Experimental and Clinical Gastroenterology. 2015; 124 (12): 6–29 (in Russian)].
20. Чиркин В.И., Ардатская М.Д., Лазарев И.А. Долгосрочные эффекты пре-парата пищевых волокон псиллиума (Мукофальк) у пациентов с мета-болическим синдромом. Клинические перспективы гастроэнтерологии, гепатологии. 2012; 1: 34–42.
[Chirkin V.I., Lazarev I.A., Ardatskaya M.D. Long-term effects of alimentary fibers agent of psyllium (Mucofalk) in patients with metabolic syndrome. Clinicheskiye perspectivy gastroenterologii, gepatologii. 2012; 1: 34–42 (in Russian)].
21. Grasset E, Puel A, Charpentier J et al. A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric NO-dependent and gut-brain axis mechanism. Cell Metab 2017; 25 (5): 1075–90.
22. Claus SP. Will gut microbiota help design the next generation of GLP-1-based therapies for type 2 diabetes? Cell Metab 2017; 26 (1): 6–7.
23. Delzenne NM, Cani PD, Everard A et al. Gut microorganisms as promising tar-gets for the management of type 2 diabetes. Diabetologia 2015; 58: 2206–17.
24. Olivares M, Schüppel V Hassan AM et al. The potential role of the dipeptidyl peptidase-4-like activity from the gut microbiota on the host health. Front Mi-crobiol 2018; 9: 1900.
25. Sikalidis AK, Maykish A. The Gut Microbiome and Type 2 Diabetes Mellitus: Dis-cussing a Complex Relationship. Biomedicines 2020; 8 (1): 8.
26. Petersen C, Round JL. Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 2014; 16: 1024–33.
27. Liou AP, Paziuk M, Luevano JM et al. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med 2013; 5: 178ra41.
28. Ding S, Chi MM, Scull BP et al. High-fat diet: Bacteria interactions promote in-testinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PLoS ONE 2010; 5: e12191.
29. Saad MJA, Santos A, Prada PO. Linking gut microbiota and inflammation to obesity and insulin resistance. Physiology 2016; 31: 283–93.
30. Bouter K, van Raalte D, Groen A, Nieuwdorp M. Role of the Gut Microbiome in the Рathogenesis of Obesity and Obesity-Related Metabolic Dysfunction. Gas-troenterology 2017; 152: 1671–8.
31. Hartstra AV, Bouter KE, Bäckhed F, Nieuwdorp M. Insights into the role of the microbiome in obesity and type 2 diabetes. Diabetes Care 2015; 38 (1): 159–65.
32. Ткач С.М., Дорофеева А.А. Соотношение основных филотипов кишечной микробиоты у больных сахарным диабетом 2-го типа. Клиническая эн-докринология и эндокринная хирургия. 2018; 3 (63): 7–14.
[Tkach S., Dorofeeva A. The ratio of the main types of intestinal microbiota in patients with type 2 diabetes mellitus. Clinical endocrinology and endocrine surgery 2018; 3 (63): 7–14 (in Russian)].
33. Ураков А.Л., Гуревич К.Г., Сорокина Ю.А. и др. Взаимосвязь клинической эффективности сахароснижающих препаратов, микробиоты кишеч-ника, рациона питания и генотипа пациента при сахарном диабете 2-го типа. Обзоры по клинической фармакологии и лекарственной тера-пии. 2018; 16 (4): 11–8.
[Urakov A.L., Gurevich K.G., Sorokina I.A. et al. Relationship of clinical efficacy of glucose lowering agents, gut microbiota, diet, and patient’s genotype in di-abetes mellitus type 2. Reviews on Clinical Pharmacology and Drug Therapy 2018; 16 (4): 11–8 (in Russian)].
34. Grasset E, Puel A, Charpentier J et al. A specific gut microbiota dysbiosis of type 2 diabetic mice induces glp-1 resistance through an enteric no-dependent and gut-brain axis mechanism. Cell Metab 2017; 26 (1): 278.
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